2018طΪĸΰƺPD-1ƼΪҩΪҹΰƴһʷǰķ籩ǰҩƲԣԼϵͳΰȾֲֶεĺչֵġԼDZðεơ롢ڿڵĸΰƽĿһ£ѡЩϵͳơ˵ͷٽΰƽġںϡҽıٴʵƸ֡202131գطȸΰϵͳҩġ2020ҽĿ¼ʽã־ⳡΰơʽ
2021327գڹٿġ -طȫҽлᡱ˹ڸΰƸĶרǡ硰ڹ֤ͬףһҹΰƾʷʱ̵ͬʱҲһȫδĸΰۺƵѧ֡
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תǬƪ·ֱɻҽԺƸֲڣѧɽҽԺƸΡѧΰоݴںѧɽҽԺҽʦ½ⷢԡ
гĿǰпΪΰߴֶΣǣҹ60%ĸΰڷʱѽչΪгڸΰøгΰתΪгΰΪǰΰƵһȵ㻰⣬ҲǸΰٴоһҪطƴĸ߿ۻʣORRԼ(DCR)ȻΪгΰתƴȫ»
2018꣬ٴѧᣨASCO״ιطPD-1Ƽ鵥׳Ƶġϡ һƲгϸIbоչʾطPD-12020ASCOṫĸоʾ mRECISTġ֡ϵORRﵽ46%λ棨mOSﵽ22.0¡
ָ ΰϵͳҩطȶеСӿҩＰƵϲԴߵORRؿָЩгڸΰںתΪгʹǰڸΰĻᡣ
2020 ASCOϣѧɽҽԺԺʿܼڴĸŶӻ㱨ʵطȰҩϲͬPD1ڲгΰתתƵЧʾоʱо6011ߣ18.3%г9ʵʩгڱδϣݴڷ˾尸
ݴΪδֲϵͳҩڸΰתпɷӸãиӦǰ
һΰƵǰעȵ㻰ǸΰԤȻгǵǰΰƵһҪֶΣ긴ʴ60%߸谭ΰЧһҪϰ
2020ASCOϣѧɽҽԺŶǣͷչطϸζ˨TACEΣϸƵٴоLANCENCT03838796ڷ
ǰԤΰΣ ƺTACE֮⣬ֶζȱѭ֤ҽѧ֤ݣ Ҫ֤µƲԡطƲгϸչڣPFS չʱ䣨TTP ORRȷطᡣ
½ָȻTACEΣջߵһЧֶΣ ǵTACEЧܻġLANCEоѡTACEطһǿǿΪƷЧ
δݴѧһҽԺƿڣɽѧҽԺӰںɽѧһҽԺΡйCSCOרίḱίԱƽⷢԡ
ΰĽǾɶܵζ˨Ѫܺ/ҩһ־ֲֶΣTACEζעƣHAICζ˨TAEԼζ˨TAREĿǰڹڣTACEѳΪԭԸϸHCCƵѡҲĿǰӦ㷺ķнƵٴʵռ91.44%2019ҹίġԭԸΰƹ淶2019棩УTACEƵָ֤ΧҲܹ㣬ǸΰڵIbڵIIIbڣ˵ǰԤİž˨ĸϸ
ǣ TACEڸΰҲھԡһTACE˨ѴﵽȫаϸȱѧԿɷı䣬ӶиǿֳϮһTACEԸסӲȻߵĸιɽϴĸ
ڷTACEϰƲгϸľͰΪTACEߺͰڸΰооٴӦǰˡҪ̽ƽ뼼ͬʱˡҪΪоٴѧҡ
ڷطTACEưɽϴHCCTACEHCC ԼHCCϲPVTTߵĶٴоʾطTACEڸΰľDZΪطΪƷΪӳPFSҲΪϵͳƴͻORR棻ٴݵʵӦãʾĿЧ
ƽΪΰϵͳƵʵ̽ı棬˻MDTۺĶϽưƽǿͰƴЭͬã磬ӿѪƸıԾֲԵЭͬãƼTϸӦϸPD-L1ʹƷСˣϵͳϽýơϳڸΰá
δĴѧҽԺĸڡѧҽԺܾںѧɽҽԺڿƳⷢԡ
ȻǴڣΪ תǬ͡δĺȫƵ½չٴʵѱδѧ߳
ڷ˰ƸϵͳûƣǿߴЭͬãܾͨʵʲչʾ˰־ֲֶƸϸٴӦDZսϵͳػعܽ˵ǰİߵĸƷоչ˵ǰϵͳҩоȵͷ
ָѪܰҩƼǵǰʵоһȵ㣻ڸϸУʹʱطΪİҩƻʯ
ӲгΰתƵΰΧڵĸΣԤԽΪڸΰۺƵΪʯĸΰۺƣѿΰϵͳĸΰơϯΰܸΰƸ֡Ŀǰܾδƺ¶ۡΨһĿܾDZ仯
ǿԿ϶ǣⳡıΰٴʵġҹڸΰߵijԤطҽĿ¼ⳡһ̱ⳡԸٶϯ
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